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Entries for the source DrugAge (516)

3920: Gruber et al. (2007) "Evidence for a trade-off between survival and fitness caused by resveratrol treatment of Caenorhabditis elegans." Ann. N. Y. Acad. Sci. 1100:530-542 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Oxidative Stress
- Paraquat/pharmacology
- Antioxidants/pharmacology
- Cell Aging
- Cell Survival
- Time Factors
- Models, Chemical
- Caenorhabditis elegans
- Stilbenes/pharmacology
- Polyphenols
- Caenorhabditis elegans Proteins/physiology
- Metabolic Networks and Pathways
- Wine
- Flavonoids/chemistry
- Helminth Proteins/physiology
- Phenols/chemistry
4643: Grünwald et al. (2013) "Longevity in the red flour beetle Tribolium castaneum is enhanced by broccoli and depends on nrf-2, jnk-1 and foxo-1 homologous genes." Genes Nutr 8(5):439-448 (PubMed)

1 citation in connected databases
4674: Guan et al. (2017) "Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism." Aging Cell 16(2):226-236 (PubMed)

6 citations in connected databases
- Tags:
- Animals
- PC12 Cells
- Rats
- Reactive Oxygen Species/metabolism
- Antioxidants/pharmacology
- Models, Biological
- Binding Sites
- Free Radical Scavengers/metabolism
- Caenorhabditis elegans/drug effects/physiology
- Longevity/drug effects/physiology
- Oxidative Stress/drug effects
- Gene Knockdown Techniques
- Amino Acids/metabolism
- Drosophila melanogaster/drug effects/physiology
- Cytoprotection/drug effects
- Sulfides/pharmacology
- Protective Agents/pharmacology
- Biocatalysis/drug effects
- Methionine Sulfoxide Reductases/metabolism
3999: Guan et al. (2010) "A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans." Free Radic. Res. 44(7):813-820 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Forkhead Transcription Factors
- Animals, Genetically Modified
- Genes, Helminth
- Gene Expression Profiling
- Transcription Factors/deficiency/genetics/physiology
- Hot Temperature
- Caenorhabditis elegans Proteins/biosynthesis/genetics/physiology
- Oligopeptides/pharmacology
- Paraquat/toxicity
- Oxidative Stress/drug effects
- Longevity/drug effects/genetics
- Aging/drug effects/genetics
- Gene Knockdown Techniques
- Stress, Physiological/drug effects
- Caenorhabditis elegans/drug effects/genetics/physiology
- Drug Evaluation, Preclinical
- Hemin/analogs & derivatives/pharmacology
- Sirtuins/biosynthesis/deficiency/genetics/physiology
- Succinate Dehydrogenase/deficiency/physiology
4783: Guerrero-Rubio et al. (2021) "Flavonoids' Effects on " Antioxidants (Basel) 10(3): (PubMed)

35 citations in connected databases
4070: Guha et al. (2013) "The longevity effect of cranberry extract in Caenorhabditis elegans is modulated by daf-16 and osr-1." Age (Dordr) 35(5):1559-1574 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Signal Transduction
- Forkhead Transcription Factors
- RNA/genetics
- Gene Expression Regulation, Developmental
- Stress, Physiological
- Transcription Factors/biosynthesis/genetics
- Caenorhabditis elegans
- Longevity/drug effects/genetics
- Caenorhabditis elegans Proteins/biosynthesis/genetics
- Real-Time Polymerase Chain Reaction
- Plant Extracts/pharmacology
- Vaccinium macrocarpon
4148: Guha et al. (2014) "Supplement timing of cranberry extract plays a key role in promoting Caenorhabditis elegans healthspan." Nutrients 6(2):911-921 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Caenorhabditis elegans/physiology
- Longevity/drug effects
- Dietary Supplements
- Plant Extracts/pharmacology
- Fruit/chemistry
- Polyphenols/pharmacology
- Vaccinium macrocarpon/chemistry
4782: Gutierrez-Zetina et al. (2021) "Caffeic and Dihydrocaffeic Acids Promote Longevity and Increase Stress Resistance in " Molecules 26(6): (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Antioxidants/pharmacology
- Longevity/drug effects
- Signal Transduction/drug effects
- Oxidative Stress/drug effects
- Stress, Physiological/drug effects/genetics
- Caenorhabditis elegans Proteins/drug effects/metabolism
- Caenorhabditis elegans/drug effects/metabolism
- Caffeic Acids/metabolism/pharmacology
- Gene Expression/drug effects/genetics
- Transcription Factors/drug effects
4065: Hada et al. (2013) "D-chiro-inositol and pinitol extend the life span of Drosophila melanogaster." J. Gerontol. A Biol. Sci. Med. Sci. 68(3):226-234 (PubMed)

4 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Signal Transduction
- Starvation
- Fertility/drug effects
- Longevity/drug effects
- Drosophila melanogaster/physiology
- Ribosomal Protein S6 Kinases/metabolism
- Drosophila Proteins/metabolism
- Forkhead Transcription Factors/metabolism
- Locomotion/drug effects
- Stress, Physiological/drug effects
- MAP Kinase Kinase 4/metabolism
- Inositol/analogs & derivatives/pharmacology
4665: Han et al. (2017) "Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan." Nature 544(7649):185-190 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Up-Regulation
- Gene Expression Regulation, Enzymologic
- Down-Regulation
- Longevity/drug effects/physiology
- Lysine/metabolism
- Methylation
- Aging/drug effects/metabolism
- Histones/chemistry/metabolism
- Intestinal Mucosa/metabolism
- Lipid Metabolism/drug effects
- Caenorhabditis elegans/drug effects/enzymology/genetics/physiology
- Dietary Fats/administration & dosage/metabolism/pharmacology
- Fatty Acid Desaturases/genetics/metabolism
- Fatty Acids, Unsaturated/administration & dosage/metabolism/pharmacology
- Germ Cells/enzymology/metabolism
- Histone-Lysine N-Methyltransferase/deficiency/metabolism
- Intestines/enzymology
- Ribosomal Protein S6 Kinases, 70-kDa/deficiency/metabolism
- Stearoyl-CoA Desaturase
4642: Han et al. (2017) "Microbial Genetic Composition Tunes Host Longevity." Cell 169(7):1249-1262.e13 (PubMed)

26 citations in connected databases
- Tags:
- Animals
- Gene Deletion
- Longevity
- Transcription Factors/metabolism
- Aging/metabolism
- Models, Animal
- Amyloid beta-Peptides/metabolism
- Escherichia coli/genetics/metabolism
- Caenorhabditis elegans Proteins/metabolism
- Genome-Wide Association Study
- Polysaccharides/metabolism
- Unfolded Protein Response
- Bacterial Load
- Caenorhabditis elegans/metabolism/microbiology
- Mitochondrial Dynamics
4189: Hans et al. (2015) "Impacts of metformin and aspirin on life history features and longevity of crickets: trade-offs versus cost-free life extension?" Age (Dordr) 37(2):31 (PubMed)

8 citations in connected databases
- Tags:
- Animals
- Female
- Male
- Longevity/drug effects/physiology
- Metformin/pharmacology
- Aspirin/pharmacology
- Gryllidae/drug effects/physiology
3849: Harrington and Harley (1988) "Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans." Mech. Ageing Dev. 43(1):71-78 (PubMed)

7 citations in connected databases
- Tags:
- Animals
- Antioxidants/pharmacology
- Longevity/drug effects
- Reproduction/drug effects
- Caenorhabditis/drug effects/growth & development/physiology
- Vitamin E/pharmacology
4126: Harrison et al. (2014) "Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males." Aging Cell 13(2):273-282 (PubMed)

3 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Body Weight
- Survival Analysis
- Longevity/drug effects
- Estradiol/pharmacology
- Masoprocol/pharmacology
- Biomarkers/metabolism
- Acarbose/pharmacology
- Methylene Blue
4804: Harrison et al. (2019) "Acarbose improves health and lifespan in aging HET3 mice." Aging Cell 18(2):e12898 (PubMed)

7 citations in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred C3H
- Mice, Mutant Strains
- Longevity/drug effects
- Acarbose/administration & dosage/analysis/pharmacology
- Healthy Aging/drug effects
3981: Harrison et al. (2009) "Rapamycin fed late in life extends lifespan in genetically heterogeneous mice." Nature 460(7253):392-395 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Mice
- Female
- Male
- Disease Susceptibility
- Survival Analysis
- Time Factors
- Diet
- Specific Pathogen-Free Organisms
- TOR Serine-Threonine Kinases
- Aging/drug effects/genetics/physiology
- Longevity/drug effects/genetics/physiology
- Carrier Proteins/antagonists & inhibitors/metabolism
- Administration, Oral
- Phosphotransferases (Alcohol Group Acceptor)/antagonists & inhibitors/metabolism
- Sirolimus/administration & dosage/pharmacology
3974: Hashimoto et al. (2010) "Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16." Biogerontology 11(1):31-43 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Forkhead Transcription Factors
- Dose-Response Relationship, Drug
- Life Expectancy
- Transcription Factors/metabolism
- Sirtuins/metabolism
- Caenorhabditis elegans/drug effects/physiology
- Aging/drug effects/physiology
- Longevity/drug effects/physiology
- Caenorhabditis elegans Proteins/metabolism
- Antioxidants/administration & dosage
- NAD/pharmacology
3894: Havermann et al. (2014) "Caffeic acid phenethylester increases stress resistance and enhances lifespan in Caenorhabditis elegans by modulation of the insulin-like DAF-16 signalling pathway." PLoS ONE 9(6):e100256 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Forkhead Transcription Factors
- Antioxidants/pharmacology
- Transcription Factors/metabolism
- DNA-Binding Proteins/metabolism
- Insulin/metabolism
- Longevity/drug effects
- Temperature
- Signal Transduction/drug effects
- Caenorhabditis elegans Proteins/metabolism
- HCT116 Cells
- Stress, Physiological/drug effects
- Caffeic Acids/pharmacology
- Phenylethyl Alcohol/analogs & derivatives/pharmacology
- Caenorhabditis elegans/cytology/drug effects/physiology
4091: Havermann et al. (2013) "Molecular effects of baicalein in Hct116 cells and Caenorhabditis elegans : activation of the Nrf2 signaling pathway and prolongation of lifespan." J. Agric. Food Chem. 61(9):2158-2164 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Humans
- Antioxidants/pharmacology
- Caenorhabditis elegans/drug effects/physiology
- Longevity/drug effects
- Signal Transduction/drug effects
- HCT116 Cells
- NF-E2-Related Factor 2/metabolism
- Colon/drug effects/metabolism
- Flavanones/pharmacology
3978: Heidler et al. (2010) "Caenorhabditis elegans lifespan extension caused by treatment with an orally active ROS-generator is dependent on DAF-16 and SIR-2.1." Biogerontology 11(2):183-195 (PubMed)

1 citation in connected databases
- Tags:
- Animals
- Gene Deletion
- Forkhead Transcription Factors
- Reactive Oxygen Species/metabolism
- Transcription Factors/genetics/metabolism
- Enzyme Inhibitors/pharmacology
- Dose-Response Relationship, Drug
- Oxidative Stress/physiology
- Heat-Shock Proteins/metabolism
- Caenorhabditis elegans/physiology
- Models, Animal
- RNA Interference
- Sirtuins/genetics/metabolism
- Caenorhabditis elegans Proteins/genetics/metabolism
- Longevity/drug effects
- Kaplan-Meier Estimate
- Naphthoquinones/pharmacology